Tramadil is generally well tolerated, the most common adverse events being nausea and vomiting.
Tramadil, a synthetic opioid of the aminocyclohexanol group, is a centrally acting analgesic with weak opioid agonist properties, and effects on noradrenergic and serotonergic neurotransmission. In addition, tramadil opioid and nonopioid modes of action appear to act synergistically.
Tramadil has been shown to provide effective analgesia after both intramuscular and intravenous administration for the treatment of postoperative pain. Tramadil is available in formulations suitable for oral, rectal and parenteral administration.
The most important side effects of tramadil are nausea and emesis, which can often be prevented by slow injection and administration of a prophylactic antiemetic such as metoclopramide.